Effects of dietary fiber in Vervet monkeys fed “Western” diets |
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Authors: | David Kritchevsky Larry M. Davidson Daniel A. Scott J. J. Van der Watt Dennis Mendelsohn |
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Affiliation: | (1) The Wistar Institute, 19104 Philadelphia, PA;(2) AEC Institute for Life Sciences, University of Pretoria, Pretoria, South Africa;(3) Department of Chemical Pathology, University of Witwatersrand School of Medicine, Johannesburg, South Africa |
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Abstract: | Male Vervet monkeys (7/treatment) were fed a “Western” diet containing 46.2% calories as fat, 39.8% as carbohydrate and 14.0% as protein. The diet was augmented with 10% cellulose or 10% pectin. A third (control) group of seven monkeys was fed a commercial ration augmented with fruit and bread. After 34 weeks, serum cholesterol levels were elevated significantly in the two test groups compared with the controls but there was no difference between the two fiber-fed groups. Serum triglycerides were unaffected. Liver cholesterol levels were the same in all three groups but liver triglyceride levels were lower in the monkeys fed cellulose. Biliary lipids were similar in all three groups as were the calculated lithogenic indices. The average aortic sudanophilia (percent of total area) in the three groups was cellulose, 10.6±2.5; pectin, 8.1±2.5; and control, 1.1±0.4. One animal in each of the groups fed “Western” diet exhibited an atherosclerotic plaque. The results indicate that there is no difference between pectin and cellulose with regard to their effects on either lipidemia or aortic sudanophilia in Vervet monkeys fed a Western-type diet. |
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