Cress seed mucilage based buccal mucoadhesive gel of venlafaxine: in vivo,in vitro evaluation |
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Authors: | Pankaj Padmakar Nerkar Surendra Ganeshlal Gattani |
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Affiliation: | (1) Department of Pharmaceutics, R.C. Patel Institute of Pharmaceutical Education & Research, Karwand Naka, Dist-Dhule, Shirpur, 425 405, Maharashtra, India;(2) S. R. T. M. University, Vishnupuri, Nanded, Maharashtra, India |
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Abstract: | Venlafaxine is a newer antipsychotic drug which shows first pass effect. Cress seed is also called as garden cress or green
salad. This study examined the mechanical (gel strength, adhesiveness) and rheological properties of cress seed mucilage based
gels that contain different ratios of carbopol 934 P (0.5–1.5%). In addition, diffusion of venlafaxine from gel formulations
was evaluated. The selected formulation was further analyzed for pharmacokinetic parameters in rabbits. All formulations exhibited
pseudoplastic flow with thixotropy. Formulation F5 showed the Cmax of 24.19 ± 0.72 ng/ml by buccal route of administration and 17.98 ± 1.15 ng/ml by oral route of administration. The bioavailability
of F5 by buccal route was 54.44% and that of by oral route was 39.60%. A combination of the cress seed mucilage and carbopol
934 P resulted in a prolonged and higher venlafaxine delivery by buccal route of administration. |
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