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Neurochemical basis of conditioned partner preference in the female rat: II. Disruption by flupenthixol.
Authors:Coria-Avila  Genaro A; Gavrila  Alex M; Boulard  Brigitte; Charron  Natalie; Stanley  Geoffrey; Pfaus  James G
Abstract:The effects of the dopamine receptor antagonist flupenthixol were examined on the development of conditioned partner preference induced by paced copulation in female rats. In Experiment 1, ovariectomized, hormone-primed rats were conditioned to associate scented and unscented males with paced and nonpaced copulation, respectively. Females in Experiment 2 associated albino or pigmented males with paced or nonpaced copulation. Flupenthixol or saline was administered before each conditioning trial. During a final drug-free preference test, females could choose to copulate with either a pacing-related or nonpacing-related male. Saline-trained females copulated preferentially with the pacing-related male, whereas flupenthixol disrupted odor but not strain conditioning. The role of dopamine in conditioned partner preference depends on the type of stimuli to be learned. (PsycINFO Database Record (c) 2010 APA, all rights reserved)
Keywords:paced copulation  odors  sexual behavior and reward  conditioning  dopamine  flupenthixol
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