| 二甲氧基乙酰乙酸甲酯的合成研究 |
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| 引用本文： | 郭建荣,常宏宏,刘强,王利珍,魏文珑. 二甲氧基乙酰乙酸甲酯的合成研究[J]. 山西化工, 2003, 23(3): 17-19 |
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| 作者姓名： | 郭建荣 常宏宏 刘强 王利珍 魏文珑 |
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| 作者单位： | 1. 山西省机械设备成套局,山西,太原,030013
2. 太原理工大学化学工程与技术学院,山西,太原,030024 |
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| 摘 要： | 以二甲氧基乙酸甲酯和乙酸甲酯为主要原料，经甲醇钠催化，制备药物尼伐地平中间体二甲氧基乙酰乙酸甲酯。通过考察原料摩尔比、催化剂用量、加料温度、反应温度和反应时间等因素对收率的影响，得到了最佳反应条件。二甲氧基乙酰乙酸甲酯的收率可达53．3％。
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| 关 键 词： | 二甲氧基乙酸甲酯 乙酸甲酯 克莱森缩合 二甲氧基乙酰乙酸甲酯 |
| 文章编号： | 1004-7050(2003)03-0017-03 |
Study on Synthesis of Dimethoxy Methyl Aceto Acetate |
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| GUO Jian-rong,CHANG Hong-hong,LIU Qiang,WANG Li-zhen,WEI Wen-long. Study on Synthesis of Dimethoxy Methyl Aceto Acetate[J]. Shanxi Chemical Industry, 2003, 23(3): 17-19 |
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| Authors: | GUO Jian-rong CHANG Hong-hong LIU Qiang WANG Li-zhen WEI Wen-long |
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| Affiliation: | GUO Jian-rong1,CHANG Hong-hong2,LIU Qiang2,WANG Li-zhen2,WEI Wen-long2 |
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| Abstract: | A new process has been developed to synthesize dimethoxy methylaceto acetate from dimethoxyacetic methyl acetate and methyl acetate in the presence of sodium methanol as catalysis.The effects of mole ratio of raw material,amount of catalyst,reaction temperature and time on the yield are investigated.The most favorable reaction conditions is obtained.The yield of dimethoxy methyl aceto acetate can be reached 55.3 %. |
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| Keywords: | dimethoxyacetic methyl acetate methyl acetate Claisencondensation dimethoxy methyl aceto acetate |
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