Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones |
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Authors: | M Jaffar SA Everett MA Naylor SG Moore S Ulhaq KB Patel MR Stratford J Nolan P Wardman IJ Stratford |
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Affiliation: | Third Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan. |
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Abstract: | We report the cases of three patients with anorexia nervosa (AN) who each recovered rapidly after experiencing a life-threatening episode with severe thrombocytopenia. All three cases were the typical restricting-type of AN, occurring in adolescence. They refused to be admitted to a hospital until their general condition had been severely deteriorated. Their lowest platelet counts were 2.9, 4.6, and 2.3 x 10(4)/mm3, respectively. Apparent hemorrhagic tendencies, such as purpura, gingival and nasal bleeding, and gastrointestinal bleeding were observed. The bone marrow examination showed apparent hypoplasia in two patients. No evidence of disseminated intravascular coagulation or autoantibody to platelets was detected. The platelet counts recovered rapidly by water and nutritional supplementation. The recovery from the AN itself was excellent in all three patients without specific psychotherapy. |
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