The efficacy, safety and tolerability of antidepressants in late life depression: a meta-analysis |
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Authors: | N Mittmann N Herrmann TR Einarson UE Busto KL Lanct?t BA Liu KI Shulman IL Silver CA Narango NH Shear |
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Affiliation: | Division of Clinical Pharmacology, Sunnybrook Health Science Centre, University of Toronto, Canada. |
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Abstract: | BACKGROUND: To determine the efficacy, safety and tolerability of antidepressants in depressed elderly patients. METHODS: Search for randomized controlled double-blind studies evaluating atypical antidepressants (ATYPs), reversible inhibitors of monoamine oxidase-A, selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants in moderate/severe depressed patients > or = 60 years for > or = four weeks. The random effects model (single-arm; comparative) was used to aggregate efficacy, safety and dropout. RESULTS: No difference in single-arm aggregation of outcomes for four antidepressant classes. Comparative analyses showed no statistical difference between outcomes, except SSRIs had a higher response rate than ATYPs. CONCLUSION: Elderly show no differences in antidepressant class outcomes. LIMITATIONS: Heterogeneity and lack of power. CLINICAL RELEVANCE: There is little advantage for antidepressant classes over another in the aged. |
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