Young Investigator Award Presentation at the 13th Annual Meeting of the ESMRMB, September 1996, Prague Quantification of pulmonary water compartments by magnetic resonance |
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Authors: | J Lehmann J C Böck P Podrabsky W Wlodarczyk R Felix |
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Affiliation: | 1. Strahlenklinik und Poliklinik, Virchow-Klinikum, Medizinische Fakult?t der Humboldt-Universit?t Berlin, Augustenburger Platz 1, D-13353, Berlin, Germany
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Abstract: | The purpose of this study was to quantify pulmonary water compartments of total, intravascular, and extravascular lung water
in excised and perfused sheep lungs with the use of magnetic resonance imaging techniques. Total lung water was measured by
proton density maps calculated from multi-spin-echo images. Intravascular lung water was evaluated by magnetic resonance angiography
before and after injection of gadolinium diethylenetriamine penta-acetic acid polylysine, a macromolecular paramagnetic contrast
agent. Intravascular lung water was calculated from signal intensity histogram changes comparing pre- and postcontrast angiograms.
Extravascular water was calculated as the difference between total and intravascular lung water. Quantities of total and intravascular
lung water measured by magnetic resonance techniques were compared to reference results obtained from wet/dry weight gravimetry
and Evans blue dilution performed after imaging. Magnetic resonance and reference results correlated significantly (total
lung water:r=0.93,p<0.001; intravascular lung water:r=0.80,p<0.001; extravascular lung water:r=0.89,p<0.001). Therefore, we conclude that quantitative magnetic resonance techniques are potentially useful for the clinical evaluation
of pulmonary water compartments. |
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Keywords: | pulmonary magnetic resonance imaging and angiography total and intravascular and extravascular lung water gadolinium-DTPA-polylysine signal intensity histogram Evans blue dye |
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