Distance distributions in proteins: a six-parameter representation |
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Authors: | Reese, M.G. Lund, O. Bohr, J. Bohr, H. Hansen, J.E. Brunak, S. |
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Affiliation: | Department of Physics 2Center for Biological Sequence Analysis, The Technical University of Denmark DK-2800 Lyngby, Denmark |
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Abstract: | We present a statistical analysis of protein structures basedon interatomic Ca distances. The overall distance distributionsreflect in detail the contents of sequence-specific substructuresmaintained by local interactions (such as -helixes) and longerrange interactions (such as disulfide bridges and ß-sheets).We also show that a volume scaling of the distances makes distancedistributions for protein chains of different length superimposable.Distance distributions were also calculated specifically foramino acids separated by a given number of residues. Specificfeatures in these distributions are visible for sequence separationsof up to 20 amino acid residues. A simple representation, whichpreserves most of the information in the distance distributions,was obtained using six parameters only. The parameters giverise to canonical distance intervals and when predicting coarse-graineddistance constraints by methods such as data-driven artificialneural networks, these should preferably be selected from theseintervals. We discuss the use of the six parameters for determiningor reconstructing 3-D protein structures. |
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Keywords: | distance distribution/ distance geometry/ protein/ folding/ protein structure |
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