Improve Solubility and Bioavailability of Silver Sulfadiazine via Formation of Inclusion Complex by Cyclodextrin

Supramolecular nanocontainers of cyclodextrins (α-CD or β-CD)/silver sulfadiazine (SSD) were prepared by inclusion complex (IC) forming between CDs and SSD at various conditions (at room temperature and under sonic energy). Obtained nanocontainers were characterized by XRD, SEM, EDX and FTIR. Formation of inclusion complex was confirmed via significant differences between FTIR and XRD spectra of pure compounds with respect to those of the complexes. EDX analysis indicated the homogenous distribution of Ag nanoparticles in the nanocontainers. Solubility, bioavailability and in vitro dissolution of obtained SSD nanocontainers were compared with pure SSD and results show that by encapsulation of SSD, solubility improved and its release is controllable. Solubility and bioavailability of β-CD/SSD is higher than α-CD/SSD, which is related bigger β-CD cavity that can entrap a higher number of SSD molecules.