薯蔓黄酮的抗疲劳作用研究

研究薯蔓黄酮(FSPV)的抗疲劳作用。将FSPV分为高、中、低3个剂量组给小白鼠灌胃,并以0.9%生理盐水为对照。10d后记录小白鼠负重游泳时间,并用试剂盒测定血尿素氮(BUN)含量、血清乳酸脱氢酶(LDH)活力以及肝糖元、肌糖元含量等与疲劳有关的生理指标。研究结果表明,3个剂量的FSPV均能延长小白鼠的游泳时间,降低运动后BUN的增量,提高血清LDH活力,也显著增加肝糖元和肌糖元的储备量。FSPV有抗疲劳作用,且中剂量(200mg/kgbw·d)FSPV抗疲劳效果最佳。

Studies on Mice Antifatigue Effect of Flavonoids from Sweet Potato Vines

To study the antifatigue effect of flavonoids from sweet potato vines(FSPV), three doses (100, 200 and 400mg/kg bw·d) of FSPV respectively with 0.9% sodium chloride solution as control were fed to mice by instil-gavage. After 10 days, the swimming time was determined by stopwatch, and the fatigue indexes, such as blood urea nitrogen(BUN), serum lactic dehydrogenase(LDH) and liver and muscle glycogen, were assayed respectively by reagent boxes. The results showed that FSPV could prolong the swimming time and meanwhile had remarkable effects on increasing the serum LDH activity and the reserves of liver and muscle glycogen, and also decreasing increment of BUN after exercise. Finally, it was found that FSPV had obvious antifatigue effect and the medium dose of FSPV (200mg/kg bw·d) was optimum.