| 色氨酸生物合成的稳态优化 |
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| 引用本文： | 徐恭贤,冯恩民,邵诚,修志龙.色氨酸生物合成的稳态优化[J].工程数学学报,2005,22(6):975-982. |
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| 作者姓名： | 徐恭贤 冯恩民 邵诚 修志龙 |
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| 作者单位： | 大连理工大学信息与控制研究中心,大连,116024;大连理工大学应用数学系,大连,116024;大连理工大学生物科学与工程系,大连,116024 |
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| 摘 要： | 本文研究了色氨酸生物合成的稳态优化.针对色氨酸生物合成过程的三维非线性动力系统,建立了使色氨酸消耗和分泌的综合项最大的稳态优化控制模型.根据IOM方法,将非线性优化问题近似转化为线性优化问题来求解,最后得到了一个稳定而且鲁棒的稳态,在该稳态下,色氨酸产率提高为基本稳态时的9倍,这一数值结果表明了优化算法的实用性和有效性.
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| 关 键 词： | 色氨酸生物合成 稳态优化 间接优化方法 S-系统 鲁棒性 |
| 文章编号： | 1005-3085(2005)06-0975-08 |
| 收稿时间： | 2004-05-19 |
| 修稿时间： | 2004年5月19日 |
Steady-state Optimization of Tryptophan Biosynthesis |
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| XU Gong-xian,FENG En-min,SHAO Cheng,XIU Zhi-long.Steady-state Optimization of Tryptophan Biosynthesis[J].Chinese Journal of Engineering Mathematics,2005,22(6):975-982. |
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| Authors: | XU Gong-xian FENG En-min SHAO Cheng XIU Zhi-long |
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| Affiliation: | 1.Research Center of Information and Control, Dalian University of Technology, Dalian 116024; 2. Department of Applied Mathematics, Dalian University of Technology, Dalian 116024; 3. Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024 |
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| Abstract: | In this paper, the steady-state optimization of tryptophan biosynthesis in Escherichia coli is discussed. According to a novel three-dimension nonlinear dynamic model of tryptophan biosynthesis, a steady-state optimization model is established. It maximizes the accumulative term accounting for both consumption and secretion. Based on an IOM approach, the previous nonlinear optimization problem is approximately transformed to a linear optimization problem. Our results show that it is possible to attain a stable and robust steady state with a rate of tryptophan production increased about 9 times. The findings illustrate the accuracy and effectiveness of the algorithm. |
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| Keywords: | tryptophan biosynthesis steady-state optimization indirect optimization method System robustness |
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