Effects of a single ingestion of sodium taurocholate on esterified cholesterol concentration in liver and cholesterol turnover in the rat |
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Authors: | D Mathé F Chevallier |
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Affiliation: | (1) Laboratoire de Physiologie de la Nutrition, Université Paris-Sud, Batiment 447 F, 91405 Orsay, Cedex, France |
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Abstract: | The overall response of the rat’s cholesterol metabolism to a single ingestion of taurocholate (80 mg) was studied with the
isotopic equilibrium method. The bile acid production, measured by the daily14CO2 output of rats in isotopic equilibrium of 26-14C]-cholesterol, initially decreased and then increased. Conversely, the hepatic concentration of esterified cholesterol first
increased and then decreased. Moreover, the ingestion of taurocholate increasing the intestinal absorption coefficient of
dietary cholesterol increased the abosprtion and decreased the fecal excretion and the intestinal biosynthesis of cholesterol.
The balance of these last effects is an excess cholesterol inflow. The classical hypothesis of negative feedback regulation
of bile acid production fails to explain the observed biphasic effect of taurocholate. This compound, when its origin is exogenous,
appears to stimulate the storage of esterified cholesterol in the liver, at the expense of bile acid synthesis. This accumulation
rate takes into account not only the decrease in cholesterol transformation into bile acids but also the excess inflow of
cholesterol. As the exogenous taurocholate was eliminated from the body, cholesteryl ester hydrolysis occurred and provided
a supplementary source of free cholesterol for bile acid synthesis. |
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