| UPLC-MS/MS法同时测定化妆品中8种抗真菌药物的含量 |
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| 引用本文： | 范菲,郑妍,刘鹏鸣,李静静,杨会鸽.UPLC-MS/MS法同时测定化妆品中8种抗真菌药物的含量[J].香料香精化妆品,2022(1):55-57. |
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| 作者姓名： | 范菲 郑妍 刘鹏鸣 李静静 杨会鸽 |
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| 作者单位： | 西安市食品药品检验所 |
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| 摘 要： | 以电喷雾离子源(ESI)为电离源,在正离子采集模式下建立了化妆品中8种抗真菌药物(氟康唑、酮康唑、萘替芬、联苯苄唑、克霉唑、益康唑、咪康唑、灰黄霉素)含量测定的超高效液相色谱-串联质谱(UPLC-MS/MS)方法,得到了8种抗真菌药物在0.02～0.60μg/mL范围内线性关系良好;平均回收率为91.71％ ～101....
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| 关 键 词： | 化妆品 超高效液相色谱-串联质谱法(UPLC-MS/MS) 抗真菌药物 |
Simultaneous Measurement of Eight Antifungal Drugs in Cosmetics by UPLC-MS/MS |
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| FAN Fei,ZHENG Yan,LIU Pengming,LI Jingjing,YANG Huige.Simultaneous Measurement of Eight Antifungal Drugs in Cosmetics by UPLC-MS/MS[J].Flavour Fragrance Cosmetics,2022(1):55-57. |
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| Authors: | FAN Fei ZHENG Yan LIU Pengming LI Jingjing YANG Huige |
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| Affiliation: | (Xi’an Institute for Food and Drugs Control,Xi’an 710054,Shaanxi,China) |
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| Abstract: | An analytical method for simultaneous measurement of eight antifungal drugs(fluconazol,ketoconazole,naftifine,bifonazole,clotrimazole,econazole,miconazole,griseofulvin)in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)was established.Good linear relationships between the peak area and concentration were found in the ranges of 0.02-0.60μg/m L for eight components.The average recoveries were 90.71%-101.66%with the RSD less than 6%.The method is simple and accurate for simultaneous analysis of the contents of eight antifungal drugs in cosmetics.It can be used for quality control of these eight components in cosmetics. |
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| Keywords: | cosmetics UPLC-MS/MS antifungal drugs |
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