葡萄酒抑制血管紧张素转化酶活性的研究

通过体外酶学实验研究了27种不同葡萄酒对血管紧张素转化酶活性的影响。结果显示,所检测的27个葡萄酒样品均具有抑制血管紧张素转化酶活性的功能,但是抑制效果随葡萄种属、葡萄品种、发酵类型的不同而显著不同,其中东亚种葡萄酒的抑酶性显著强于欧亚种,红葡萄酒抑酶性显著强于白葡萄酒。对葡萄酒中重要的组成成分如乙醇、有机酸、多酚等对血管紧张素转化酶活性影响进行分析,结果显示乙醇对血管紧张素转化酶活性没有显著影响,总酸含量与酶活性抑制率间不具有相关性,但总酚含量与酶活性抑制率间显著相关,由此表明,葡萄酒中多酚具有一定降低血管紧张素转化酶活性的作用。

The Study on Inhibition of Angiotensin Converting Enzyme Activity by Wines

The activity of Angiotensin converting enzyme(ACE) was evaluated in the presence of 27 different kinds of wines in vitro.The results showed that all tested wines inhibited the activity of angiotensin-converting enzyme,but inhibition effects were significantly different with the differences of grape species,grape varieties and fermentation type.Among them,the Oriental Vitis species significantly was more effective than the V.vinifera,and red wines was more effective than white.When the impacts of ethanol,organic acids and polyphenols on ACE activity were analyzed,it was observed that ethanol in wines had no significant effect on ACE activity and the total content of acids showed no significant correlation with the inhibition rate of ACE while total content of phenols showed a significant correlation.Our results showed that polyphenols are beneficial in inhibiting ACE activity.