Derivatization of keto fatty acids,X: Synthesis of thiazanones |
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| Authors: | Amjadullah Khan S. Rafat Husain F. Ahmad M. S. Siddiqui W. Pimlott |
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| Affiliation: | (1) Department of Chemistry, Aligarh Muslim University, 202 001 Aligarh, India;(2) Department of Medicinal Biochemistry, Faculty of Medicine, University of Goteborg, Sweden;(3) Laboratoire de Botanique et Biologie cellulaire, UER Médicament, Avenue du Pr. Léon-Bernard, 35043 Rennes Cedex, France;(4) Present address: Department of Chemistry, Gandhi Faiz-e-Am (P.G.) College, 242 001 Shahajahanpur, India |
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| Abstract: | The synthesis of alkyl chain-substituted thiazanones from oxo fatty esters and a long chain aldehyde is reported. Four oxo compounds—methyl 10-oxoundecanoate, methyl 9-oxooctadecanoate, methyl 9,10-dioxooctadecanoate and octadecanal—were allowed to react with β-mercaptopropionic acid in the presence of ammonium carbonate in benzene to give the corresponding 4-m-thiazanones in high yields. The structures of these compounds were confirmed by combustion and spectral data. |
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