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Plasma polypyrrole implants recover motor function in rats after spinal cord transection |
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| Authors: | Cruz Guillermo J Mondragón-Lozano Rodrigo Diaz-Ruiz Araceli Manjarrez Joaquín Olayo Roberto Salgado-Ceballos Hermelinda Olayo Maria-Guadalupe Morales Juan Alvarez-Mejía Laura Morales Axayacatl Méndez-Armenta Marisela Plascencia Noel del Carmen Fernandez Maria Ríos Camilo |
| Affiliation: | 1. Departamento de Física, Instituto Nacional de Investigaciones Nucleares, Carr. México-Toluca, km 36.5, CP 52750, Ocoyoacac, Edo. Mex., Mexico 2. Departamento de Física, Universidad Autónoma Metropolitana Iztapalapa, Apdo. Postal 55-534, CP 09340, Mexico, D.F., Mexico 3. Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, Av. Insurgentes Sur 3877, CP 14269, Mexico, D.F., Mexico 4. Laboratorio de Fisiología de la Formación Reticular, Instituto Nacional de Neurología y Neurocirugía, Av. Insurgentes Sur 3877, CP 14269, Mexico, D.F., Mexico 5. Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtemoc 330, Col. Doctores, CP 06703, Mexico, D.F., Mexico 6. Centro Médico Nacional 20 de Noviembre, ISSSTE, Av. Félix Cuevas 540, Col. del Valle, CP 03229, Mexico, D.F., Mexico 7. Departamento de Electrofisiología, Instituto Nacional de Neurología y Neurocirugía, Av. Insurgentes Sur 3877, CP 14269, Mexico, D.F., Mexico |
| Abstract: | We studied the use of three biocompatible materials obtained by plasma polymerization of pyrrole (PPy), pyrrole doped with iodine (PPy/I) and a copolymer formed with pyrrole and polyethylene glycol (PPy/PEG), implanted, separately, after a complete spinal cord transection in rats. Motor function assessed with the BBB scale and somatosensory evoked potentials (SEPs) in the implanted rats were studied. Results showed that the highest motor recovery was obtained in rats with PPy/I implants. They also showed a significant reduction in the latency of SEPs. Histological analyses showed no signs of implant rejection; on the contrary, implants based on PPy improved the SEPs conduction and motor function after lesion. |
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