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Identification of Tri‐ and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors

Authors:	Dante Rotili Dr Domenico Tarantino Dr Vincenzo Carafa Dr Ester Lara Dr Sarah Meade Dr Giorgia Botta Dr Angela Nebbioso Dr Jörg Schemies Dr Manfred Jung Prof Aleksey G Kazantsev Prof Manel Esteller Prof Mario F Fraga Dr Lucia Altucci Prof Antonello Mai Prof

Affiliation:	1. Istituto Pasteur – Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le A. Moro 5, 00185 Roma (Italy), Fax: (+39)?06491491;2. Dipartimento di Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138 Napoli (Italy);3. Department of Immunology and Oncology, National Center for Biotechnology (CNB‐CSIC), Cantoblanco, Madrid (Spain);4. Harvard Medical School, Massachusetts General Hospital, CNY114 16th Street, Charlestown, MA 02129 (USA);5. Institute of Pharmaceutical Sciences, Albert‐Ludwigs‐Universit?t Freiburg, Albertstr. 25, 79104 Freiburg (Germany);6. Cancer Epigenetics and Biology Program (PEBC), Catalan Institute of Oncology (ICO), Barcelona (Spain)

Abstract:

Keywords:	antiproliferation apoptosis diazabenzoanthracene inhibitors sirtuins