Synthesis of Fatty Acid Amides of Catechol Metabolites that Exhibit Antiobesity Properties期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of Fatty Acid Amides of Catechol Metabolites that Exhibit Antiobesity Properties

Authors:	Bruno Almeida Dr Jesús Joglar María Jesús Luque?Rojas Juan Manuel Decara Francisco Javier Bermúdez‐Silva Dr Manuel Macias‐González Dr Montserrat Fitó Miguel Romero‐Cuevas Dr Magí Farré Dr María Isabel Covas Dr Fernando Rodríguez?de?Fonseca Dr Rafael de?la?Torre

Affiliation:	1. Human Pharmacology and Clinical Neurosciences Research Group, Neuropsychopharmacology Research Program, IMIM‐Hospital del Mar Research Institute, Dr. Aiguader 88, Barcelona 08003 (Spain), Fax: (+34)?933160467;2. Universitat Pompeu Fabra, CEXS‐UPF, Dr. Aiguader 88, Barcelona 08003 (Spain);3. CIBEROBN, Instituto de Salud Carlos?III, Madrid (Spain);4. Departamento de Química Biológica y Modelización Molecular, Instituto de Química Avanzada de Catalu?a (IQAC‐CSIC), Jordi Girona 18‐26, 08034 Barcelona (Spain);5. Fundación IMABIS, Hospital Carlos Haya de Málaga, Avda. Carlos Haya 82, Pabellón de Gobierno, 29010 Málaga (Spain);6. Hospital Clínico Virgen de?la Victoria, Campus Universitario Teatinos, 29010 Málaga (Spain);7. Oxidative Stress and Nutrition Research Group, Inflammation and Cardiovascular Research Program, IMIM‐Hospital del Mar, Dr. Aiguader 88, Barcelona 08003 (Spain);8. Universitat Autònoma de Barcelona, UDIMAS‐UAB, Dr. Aiguader 88, Barcelona 08003 (Spain)

Abstract:	A series of fatty acid amides of 3,4‐methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affinity for the CB₁ receptor and/or PPAR‐α; part of their biological activity may be caused by these double interactions.

Keywords:	CB1 endocannabinoids obesity PPAR‐α receptors

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