| 卵清蛋白-PLGA抗原微球脉冲释放系统的研究 |
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| 引用本文： | 曾魁,李军,黄霞.卵清蛋白-PLGA抗原微球脉冲释放系统的研究[J].广东化工,2011,38(11):10-11. |
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| 作者姓名： | 曾魁 李军 黄霞 |
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| 作者单位： | 海南大学海洋学院热带生物资源教育部重点实验室,海南海VI,570228 |
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| 基金项目： | 热带生物资源教育部重点实验室开放基金; 海南大学211工程研究生创新平台专项资金 |
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| 摘 要： | 目的：以OVA为模型抗原研制具有脉冲释放特性的OVA-PLGA微球并对其在小鼠体内的免疫效果进行评价。方法：复乳法研制OVA-PLGA微球;光学显微镜和电子显微镜法研究微球的形态、粒径和粒径分布;Bradford法测定微球的载药量和包封率;微量溶出度测定法研究微球的体外释放规律;按注射剂的要求研制含OVA-PLGA微球...
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| 关 键 词： | 卵清蛋白 PLGA 微球 脉冲释放 |
Study on Ovalbumin-PLGA Antigen Microspheres Pulsatile Release System |
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| Zeng Kui,Li Jun,Huang Xia.Study on Ovalbumin-PLGA Antigen Microspheres Pulsatile Release System[J].Guangdong Chemical Industry,2011,38(11):10-11. |
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| Authors: | Zeng Kui Li Jun Huang Xia |
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| Affiliation: | Zeng Kui,Li Jun,Huang Xia(Hainan University of Key Laboratory of Tropical Biolgical Resources of Ministry of Education,the Ocean College of Hainan University,Haikou 570228,China) |
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| Abstract: | Aim: OVA was regarded as antigen model to develop OVA-PLGA microspheres with characteristics of pulsatile release,and immune effect of OVA-PLGA microspheres was evaluated in rats.Methods: OVA-PLGA microshperes were developed using double emulsion method;morphorlogy,size and size distribution was studied by optical and electron microscopy;drug loading and encapsulation efficiency was determined by Bradford method;resease of microspheres in vitro was studied by trace dissolution rate determination;OVA-PLGA su... |
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| Keywords: | OVA PLGA microsphere pulsatile release |
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