Bilateral tubo-ovarian abscesses four years after total abdominal hysterectomy |
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Authors: | LE Mendez SM Bhoola IR Horowitz |
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Affiliation: | Katedra chemickej teórie lieciv Farmaceutickej fakulty Univerzity Komenského, Bratislava. |
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Abstract: | Using rat paw dextran-induced and carrageenan-induced edemas, the anti-inflammatory activity of gallic acid (I), triacetylgallic acid (II) and monohydrate copper(II) triacetylgallate (III) was assayed. All compounds tested were applied i.p. in a single dose of 50 mumol/kg body weight, calculated for the RCOO-fragment. The average antiedematous activities in dextran/carrageenan edemas were decreasing in the following order: III (55.9/41.8%) > I (38.6/31.1%) > II (-3.4/13.3%). The relationship between the biological effects found and gallic acid as well as its structural derivatives is discussed. |
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