|
|||||
|
|
| N,N′-二(2-吡啶甲酰胺基)-1,2-乙烷的合成 | |
| 引用本文： | 赵颖俊,冯晓亮,史鸿鑫,吾国强.N,N′-二(2-吡啶甲酰胺基)-1,2-乙烷的合成[J].化学世界,2008,49(11). |
| 作者姓名： | 赵颖俊 冯晓亮 史鸿鑫 吾国强 |
| 作者单位： | 1. 浙江工业大学浙西分校化学与制药工程系,浙江,衢州,324000;浙江工业大学绿色化学合成技术国家重点实验室培育基地,浙江,杭州,310014 2. 浙江工业大学浙西分校化学与制药工程系,浙江,衢州,324000 3. 浙江工业大学绿色化学合成技术国家重点实验室培育基地,浙江,杭州,310014 |
| 摘 要： | 以2-吡啶甲酸与乙二胺为原料,采用亚磷酸三苯酯法合成N,N′-二(2-吡啶甲酰胺基)-1,2-乙烷。实验结果表明优化的反应条件为:反应温度90°C,反应时间3 h,n(亚磷酸三苯酯)∶n(2-吡啶甲酸)=0.7∶1,收率为85.6%。产品经HPLC分析,含量99.2%。化合物结构经MS、IR、1H NMR确证。亚磷酸三苯酯法具有操作简便、所得产品纯度高等特点。 |
| 关 键 词： | 2-吡啶甲酸 N N′-二(2-吡啶甲酰胺基)-1 2-乙烷 亚磷酸三苯酯 合成 |
Synthesis of N,N'-Bis(2-pyridinecarboxamide)-1,2-ethane |
|
| ZHAO Ying-jun,FENG Xiao-liang,SHI Hong-xin,WU Guo-qiang.Synthesis of N,N'-Bis(2-pyridinecarboxamide)-1,2-ethane[J].Chemical World,2008,49(11). | |
| Authors: | ZHAO Ying-jun FENG Xiao-liang SHI Hong-xin WU Guo-qiang |
| Abstract: | N,N′-Bis(2-pyridinecarboxamide)-1,2-ethane was synthesized for 2-pyridine-carboxylic acid and ethylenediamie with the method of triphenyl phosphite. The optimum conditions were obtained as follows: the molar ratio of triphenyl phosphite and 2-pyridinecarboxylic acid was 0.7∶1,temperature and time of reaction were(90°C) and 3 h.The product was characterized by IR,MS and()~1H NMR.The purity of the product was 99.2% and the yield is 85.6%.The results showed that the method of triphenyl phosphite had many advantages,such as easy to operate and high-purity of the product. |
| Keywords: | 2-pyridinecarboxylic acid N N′-bis(2-pyridinecarboxamide)-1 2-ethane triphenyl phosphite synthesis |
| 本文献已被 维普 万方数据 等数据库收录！ | |