| 进化策略的一种改进及其在蛋白质结构预测中的应用 |
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| 引用本文： | 张红娟,李斌,唐焕文,郭崇慧. 进化策略的一种改进及其在蛋白质结构预测中的应用[J]. 计算机与应用化学, 2005, 22(12): 1097-1100 |
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| 作者姓名： | 张红娟 李斌 唐焕文 郭崇慧 |
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| 作者单位： | 大连理工大学应用数学系,辽宁,大连,116024;大连理工大学应用数学系,辽宁,大连,116024;大连理工大学应用数学系,辽宁,大连,116024;大连理工大学应用数学系,辽宁,大连,116024 |
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| 基金项目： | 国家自然科学基金资助项目（90103033） |
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| 摘 要： | 进化策略算法是一种模拟自然界生物进化过程的全局优化方法。本文将一种改进的进化策略算法应用于蛋白质三维HPNX非格模型，较成功地预测了蛋白质序列1RPB、1BPI和1UBQ的折叠趋势，说明了三维HPNX非格模型比简化HP非格模型更能准确地描述蛋白质的折叠情况，同时表明了进化策略算法用于蛋白质结构预测问题是可行的、有效的。
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| 关 键 词： | 进化策略 HPNX非格模型 蛋白质折叠 |
| 文章编号： | 1001-4160（2005）12-1097-1100 |
| 收稿时间： | 2005-06-15 |
| 修稿时间： | 2005-06-152005-08-16 |
An improved evolution strategies and its application to protein structure prediction |
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| ZHANG HongJuan,LI Bin,TANG HuanWen,GUO ChongHui. An improved evolution strategies and its application to protein structure prediction[J]. Computers and Applied Chemistry, 2005, 22(12): 1097-1100 |
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| Authors: | ZHANG HongJuan LI Bin TANG HuanWen GUO ChongHui |
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| Affiliation: | Department of Applied Mathematics, Dalian University of Technology, Dalian, 116024, Liaoning, China |
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| Abstract: | Evolution strategies as global optimization search methods, are computing models simulating the evolutionary mechanisms of nature. An improved evolution strategy is applied to protein 3-dimension HPNX off-lattice model, and we successfully predict the structuros of several protein sequences, such as 1RPB,1BPI and 1UBQ. These results show that HPNX off-lattice model is more accurate than HP off-lattice model in representing the folding trends of proteins and evolution strategies are feasible and effective to the prediction of protein structures. |
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| Keywords: | evolution strategies HPNX off-lattice model protein folding |
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