Bone marrow transplantation in chronic granulomatous disease |
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Authors: | MC Calvi?o MS Maldonado E Otheo A Mu?oz JM Couselo C Burgaleta |
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Affiliation: | Servicio de pediatría, Hospital Ramón y Cajal, Madrid, Spain. |
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Abstract: | We present a 5-year-old boy with a severe form of X-linked chronic granulomatous disease and hypersensitivity to sulphamides preventing prophylaxis with trimethoprim-sulphomethoxazole. Bone marrow transplantation was performed after preconditioning with busulphan and cyclophosphamide. The immediate post-transplant period was without complications. Complete chimerism was demonstrated and post-transplant oxidative metabolism was normal. The patient is asymptomatic 30 months after the graft. CONCLUSION: Bone marrow transplantation in cases of chronic granulomatous disease is controversial, although it could be useful in selected very severe cases in which prophylactic therapy is problematic. |
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