3-氨基-5-羧基-1,2,4-三唑席夫碱的合成

含1,2,4-三唑环的席夫碱化合物一般都具有很好的生物活性。为了进一步探讨1,2,4-三唑席夫碱的合成,文中以3-氨基-5-羧基-1,2,4-三唑为原料,与取代芳醛反应,合成了8个3-氨基-5-羧基-1,2,4-三唑类席夫碱化合物。采用的反应条件为:3-氨基-5羧基-1,2,4-三唑与取代芳醛的摩尔比为1∶1,N,N-二甲基甲酰胺(DMF)为溶剂,冰醋酸为催化剂,在回流温度下反应3.5—4.5 h。化合物的结构通过IR,1H NMR和元素分析进行了表征。样品分析结果表明,在红外光谱中,所得目标产物在波数ν=1 600—1 625 cm-1处均出现C N的特征吸收峰;在1H核磁共振中,化学位移δ9附近有CH N的质子的化学位移出现。

Synthesis of 3-amino-5-carboxyl-1,2,4-triazole Schiff bases

Schiff bases of 1,2,4-triazole are normally with good biological activity.In order to further discuss their synthesis,eight Schiff bases of 3-amino-5-carboxyl-1,2,4-triazole derivatives were synthesized by condensation of 3-amino5-carboxyl-1,2,4-triazole with substituted aromatic aldehydes in the presence of glacial acetic acid as catalyst.The reaction was carried in N,N-dimethyl formamide(DMF) under refluxing for 3.5-4.5 h with molar ratio of 3-amino-5-carboxyl-1,2,4-triazole to aromatic aldehyde 1∶1.The structures of the compounds were confirmed by IR,1H NMR and elemental analysis.The results show that all the compounds obtained have the CN characteristic absorption band at ν=1600-1625 cm-1 in the IR and the proton chemical shift of CHN around δ9 in the 1H NMR.