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Effect of treatment with simvastatin on bone microarchitecture of the femoral head in an osteoporosis animal model
Authors:Lucas Oliveira Monteiro  Ana Paula Macedo  Roberta Carminati Shimano  Antônio Carlos Shimano  Gabriela Rezende Yanagihara  Junia Ramos  Marina Ribeiro Paulini  Fellipe Augusto Tocchini de Figueiredo  Miliane Gonçalves Gonzaga  João Paulo Mardegan Issa
Affiliation:1. Department of Morphology, Physiology, and Basic Pathology, School of Dentistry of Ribeir?o Preto, University of S?o Paulo, S?o Paulo, Brazil;2. Bioengineering Laboratory, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeir?o Preto Medical School, University of S?o Paulo, S?o Paulo, Brazil
Abstract:The objective of this study was to evaluate the microarchitecture and trabecular bone strength at the distal region of the femur, and its biomechanical properties with simvastatin administration with two different doses in ovariectomized (OVX) rats. Ninety rats were divided into six groups to evaluate treatment with the simvastatin drug (n = 15): SH (Sham surgery), SH‐5 (5 mg simvastatin), SH‐20 (20 mg simvastatin), OVX, OVX‐5, and OVX‐20. Euthanasia was performed at three different times, five animals per period: 7, 14, and 28 days. The effectiveness of the treatments was evaluated by mechanical testing and histomorphometric analysis of the femurs. The results of analysis by the linear model of mixed effects showed 20 mg of simvastatin results in increased trabecular bone after 14 days (P = 0.039) of ingestion in ovariectomized animals. However, ingestion of 5 mg of simvastatin is able to sensitize the trabecular bone only at 28 days (P = 0.005) of ingestion. In the mechanical tests stiffness improves within 28 days (P = 0.003). Regarding maximum strength, no statistical differences were observed. According to these results, it can be concluded that for a decrease in oral intake, longer treatment times are required. Microsc. Res. Tech. 79:684–690, 2016. © 2016 Wiley Periodicals, Inc.
Keywords:metabolic bone disease  ovariectomy and statins
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