| 氧化铝干柱固相萃取结合紫外导数光谱法快速测定全血安定 |
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| 引用本文： | 杨晓兰,黄维,马育. 氧化铝干柱固相萃取结合紫外导数光谱法快速测定全血安定[J]. 化工时刊, 2005, 19(9): 20-22 |
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| 作者姓名： | 杨晓兰 黄维 马育 |
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| 作者单位： | 重庆医科大学生物材料与药物化学研究室,重庆,400016;重庆交通学院化学教研室,重庆,400074 |
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| 基金项目： | 重庆市医学科技计划资助项目（99-2032） |
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| 摘 要： | 建立一种简便的血中安定的测定方法.采用氧化铝干柱层析固相萃取血中安定,紫外二阶导数光谱法测定萃取液中安定药物浓度.对于血液中安定含量在mg/L级时,pH=7条件下的萃取回收率〉89%,RSD〈10%.本方法简便易行、材料价廉,对于含安定mg/L级的血样,测定结果准确可靠,批量测试更省时间.
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| 关 键 词： | 固相萃取 紫外导数光谱法 氧化铝 安定 血 |
| 收稿时间： | 2005-05-25 |
| 修稿时间： | 2005-05-25 |
Determination of Diazepam in Blood with Solid-phase Extraction Chromatography on Alumina Dry column |
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| Yang Xiaolan,Huang Wei,Ma Yu. Determination of Diazepam in Blood with Solid-phase Extraction Chromatography on Alumina Dry column[J]. Chemical Industry Times, 2005, 19(9): 20-22 |
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| Authors: | Yang Xiaolan Huang Wei Ma Yu |
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| Abstract: | To establish a method for extracting and determining diazepam in blood.Diazepam was isolated from blood with solid-phase extraction chromatography on alumina dry column and then detected with UV 2ndderivative spectra.More than 89 % of diazepam was recovered with RSD less than 10 %(n = 4).The method for determining diazepam in blood is simple,convenient,cost-effective,and reliable at the level of mg/L with a good repeatability and high extraction rates,What's more,it is lime-saving when dealing with batch sample. |
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| Keywords: | solid - phase extraction Ultraviolet derivative spectra alumina diazepam blood. |
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