Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. I. Taxonomy, fermentation, isolation and antimicrobial activities |
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| Authors: | N Matsumoto T Tsuchida M Umekita N Kinoshita H Iinuma T Sawa M Hamada T Takeuchi |
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| Affiliation: | Institute of Microbial Chemistry, Tokyo, Japan. |
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| Abstract: | A new structural class of the antibiotic, epoxyquinomicins A, B, C and D were isolated from the culture broth of the strain MK299-95F4, which was related to Amycolatopsis sulphurea. Antimicrobial activity of epoxyquinomicins A and B were weak against Gram-positive bacteria, and epoxyquinomicins C and D showed almost no antimicrobial activity and no cytotoxicity. All these antibiotics showed improvement of collagen induced arthritis in vivo. |
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