| 丙硫菌唑的合成 |
| |
| 引用本文： | 王美娟,廖道华,曾仲武,李超,吴忠信,杨芳,师文娟. 丙硫菌唑的合成[J]. 农药, 2009, 48(3) |
| |
| 作者姓名： | 王美娟 廖道华 曾仲武 李超 吴忠信 杨芳 师文娟 |
| |
| 作者单位： | 1. 华东理工大学,制药工程系,上海,200237
2. 浙江禾本农药化学有限公司,浙江,温州,325008 |
| |
| 摘 要： | 以1-氯-1-氯乙酰基环丙烷为起始原料经格式反应、缩合反应、硫的亲电加成反应合成了目标产物丙硫菌唑,缩合反应中用水代替DMF做溶剂,提高了产率,节约了成本.丙硫菌唑的总收率31.1%,含量99.3%.产物经1H NMR、MS进行了表征.
|
| 关 键 词： | 丙硫菌唑 1-氯-1-氯乙酰基环丙烷 杀菌剂 合成 |
Synthesis of Prothioconazole |
| |
| WANG Mei-juan,LIAO Dao-hua,ZENG Zhong-wu,LI Chao,WU Zhong-xin,YANG Fang,SHI Wen-juan. Synthesis of Prothioconazole[J]. Pesticides, 2009, 48(3) |
| |
| Authors: | WANG Mei-juan LIAO Dao-hua ZENG Zhong-wu LI Chao WU Zhong-xin YANG Fang SHI Wen-juan |
| |
| Affiliation: | 1.College of Chemistry and Pharmaceutical Engineering;East China University of Science and Technology;Shanghai 200237;China;2.Zhejiang Heben Pesticide & Chemicals Co.;Ltd.;Wenzhou 325008;Zhejiang;China |
| |
| Abstract: | Prothioconazole was synthesized from 1-chloro-1-chloro-acetyl-cyclopropane via Grignard reaction, con- densation and electrophilic addition of sulphur powder. The yield was increased and the cost was reduced while water was used as solvent instead of absolute DMF in the condensation. The total yield of prothioconazole was 31.1%, and the content was 99.3%. The products were determined by 1H NMR and MS. |
| |
| Keywords: | prothioconazole 1-chloro-1-chloro-acetyl-cyclopropane fungicide synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
