Vestibular lesions selectively abolish body rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats. |
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Authors: | Ossenkopp, Klaus-Peter Parker, Linda A. Limebeer, Cheryl L. Burton, Page Fudge, Melissa A. Cross-Mellor, Shelley K. |
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Abstract: | Pairing a novel taste with provocative vestibular stimulation results in conditioned taste aversions in both rats and humans. Vestibular system involvement in gustatory conditioning was examined in sham-lesioned or labyrinthectomized rats. Three conditioning trials consisted of 30 min access to a saccharin (0.1%) solution followed by 30 min of rotation (70 rpm) or sham rotation. In a taste reactivity test with saccharin, rotated sham-lesioned rats, but not labyrinthectomized rats, exhibited increased oral rejection reactions compared with control rats. When conditioned with lithium chloride, both labyrinthectomized and sham-lesioned rats displayed robust conditioned rejection reactions. The finding that normal vestibular function is necessary in obtaining rotation-induced conditioned taste aversions supports the face and construct validity of a rat model of motion sickness. (PsycINFO Database Record (c) 2010 APA, all rights reserved) |
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Keywords: | conditioned taste aversions gustatory conditioning vestibular lesions labyrinthectomy lithium body rotation rats model of motion sickness |
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