Inhibitory effects of Na2SeO3 on Tca8113 cells in vitro and in vivo

In the study, Na2SeO3 effectively limited the growth and proliferation of Tca8113 cells both in vitro and in vivo. The response was dependent on the dose, the starting administered time, exposed length of selenium and density of inoculated Tca8113 cells. At 1 microgram/ml dose of selenium, there were remarkable inhibitory effects while no detectable inhibitory effect to L929 cells. 1 microgram/ml dose for less than 24 hours, the growth and proliferative ability of Tca8113 cells was reversal whereas more than that period, was irreversal. In vivo experiment, the morbidity of transplanted tumors was remarkably depressed with Se-intraperitoneal injection. At 60 micrograms/ip dose, the weight of nude mice were not reduced and the pathological changes in liver and kidney had not found.