| 强酸性离子交换膜催化合成二氢嘧啶酮药物中间体 |
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| 引用本文： | 李治,倪淑晶,施婷婷.强酸性离子交换膜催化合成二氢嘧啶酮药物中间体[J].应用化工,2004,33(5):36-38. |
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| 作者姓名： | 李治 倪淑晶 施婷婷 |
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| 作者单位： | 华东理工大学,化学与制药学院,上海,200237 |
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| 摘 要： | 在HF 101强酸性离子交换膜的存在下,由对羟基苯甲醛、乙酰乙酸甲酯与脲一步合成了5 甲氧羰基 4 (4 甲氧苯基) 6 甲基 3,4 二氢嘧啶 2(1H) 酮。当对羟基苯甲醛、乙酰乙酸甲酯与脲的摩尔比为1∶2∶5,乙醇作溶剂,3g离子交换膜,回流2h,产物收率达95.4%。同时研究了离子交换膜作为催化剂的重复使用情况。
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| 关 键 词： | 强酸型离子交换膜 催化 药物中间体 5-甲氧羰基-4-(4-甲氧苯基)-6-甲基-3 4-二氢嘧啶-2(1H)酮 |
| 文章编号： | 1671-3206(2004)05-0036-02 |
| 修稿时间： | 2004年3月24日 |
Catalytic synthesis of 5-methoxycarbonyl-4 (4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-one by strong acidic ion-exchange membrane |
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| LI Zhi,NI Shu-jing,SHI Ting-ting.Catalytic synthesis of 5-methoxycarbonyl-4 (4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-one by strong acidic ion-exchange membrane[J].Applied chemical industry,2004,33(5):36-38. |
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| Authors: | LI Zhi NI Shu-jing SHI Ting-ting |
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| Abstract: | 5-methoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-one was synthesized from anisaldehyde, methyl acetoactate and urea in presence of HF-101 strong acidic ion-exchange membrane.The yield of the 3,4-dihydropyrimidine-2(1H)-one was up to 95.4% under mole ratio of anisaldehyde, methyl acetoactate and urea is 1∶2∶5, ion-exchange membrane is 3 g,ethyl alcohol as solvent and refluxing for 2 h.The reusability of the catalyst was studied. |
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| Keywords: | strong acidic ion-exchange membrane catalysis pharmaceutical intermediate 5-methoxycarbonyl-4-(4-methoxyphenyl)-6-methyl-3 4-dihydropyrimidine-2(1H)-one |
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