|
|||||
|
|
| 用RP-HPLC法测定环合酯中的1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸乙酯的含量 | |
| 引用本文： | 张龙庄,张璐,付彦文.用RP-HPLC法测定环合酯中的1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸乙酯的含量[J].应用化工,2008,37(8). |
| 作者姓名： | 张龙庄 张璐 付彦文 |
| 作者单位： | 1. 西安市产品质量监督检验所,陕西,西安,710026 2. 陕西师范大学,化学与材料科学学院,陕西,西安,710061 3. 陕西省石油化工研究设计院,陕西,西安,710054 |
| 摘 要： | 建立了以甲醇-水为流动相,使用C18柱进行分离的反向液相色谱法测定环合酯中的1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸乙酯含量的分析方法,检测波长为254 nm,甲醇与水的比例为80∶20,柱温为40℃。方法的RSD=0.85%,加标回收率为98.0%~99.8%,最低检测限为0.06μg/mL。该方法操作简便、快速、准确。 |
| 关 键 词： | 1-环丙基-6 7-二氟-1 4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸乙酯 液相色谱 甲醇-水 |
RP-HPLC determination of 1-cyclopropyl-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-ethyl carboxylate in its preparations |
|
| ZHANG Long-zhuang,ZHANG Lu,FU Yan-wen.RP-HPLC determination of 1-cyclopropyl-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-ethyl carboxylate in its preparations[J].Applied chemical industry,2008,37(8). | |
| Authors: | ZHANG Long-zhuang ZHANG Lu FU Yan-wen |
| Abstract: | ARP-HPLC method for the determination of 1-cyclopropyl-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-ethyl carboxylate in its preparations was developed using C18 column.The mobile phase consisted of methanol and water(80 ∶20) and the column temperature was 40 ℃.The detection limit was 0.06 μg/mL.The detection wavelength was 254 nm,the recovery was 98.0%～99.8%,the RSD was 0.85%,the method is simple,fast and accurate. |
| Keywords: | 1-cyclopropyl-6 7-difluoro-8-methyl-1 4-dihydro-4-oxoquinoline-3-ethyl carboxylate HPLC methanol-water |
| 本文献已被 维普 万方数据 等数据库收录！ | |