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Small-diameter vascular grafts of Bombyx mori silk fibroin prepared by a combination of electrospinning and sponge coating |
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| Authors: | Michiko Sato Yasumoto Nakazawa Kimie Tanaka Derya Aytemiz |
| Affiliation: | a Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan b Nature and Science Museum, Tokyo University of Agriculture and Technology, Tokyo, Japan c Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan d Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan |
| Abstract: | The present study aimed to produce small-diameter grafts made of a silk fibroin by electrospinning. In order to reinforce the electrospun silk fibroin graft (ES), the graft was coated with a silk sponge (ESSC). Physical properties such as a diameter of the electrospun silk fibers were influenced by a concentration of fibroin solution. Ultimate tensile strength (UTS) of the ESSC graft was improved compared to the ES graft. However, the ESSC graft was less compliant than the ES graft. Importantly, water permeability of the ESSC graft was within the range of which endothelialization was promoted in previous studies. |
| Keywords: | Small-diameter vascular graft Silk fibroin Electrospinning |
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