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In vitro corrosion and cytotoxicity on microcrystalline, nanocrystalline and amorphous NiTi alloy fabricated by high pressure torsion |
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| Authors: | FL Nie Y Cheng RZ Valiev |
| Affiliation: | a State Key Laboratory for Turbulence and Complex System and Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871, China b Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China c Department of Oral and Maxillofacial Surgery, School of Stomatology, Peking University, Beijing 100081, China d Institute of Physics of Advanced Materials, Ufa State Aviation Technical University, Ufa, Russia |
| Abstract: | Bulk nanocrystalline and amorphous Ni50.2Ti49.8 alloy samples were successfully prepared from commercial microcrystalline Ni50.2Ti49.8 alloy discs by high pressure torsion (HPT) technique. Then their corrosion resistance, surface wettability and cytotoxicity were further studied from the viewpoint of biomaterials. In both Hank's solution and artificial saliva, bulk nanocrystalline and amorphous Ni50.2Ti49.8 alloys showed significantly higher pitting corrosion potentials than that of microcrystalline Ni50.2Ti49.8 alloy. Meanwhile, the amount of Ni ion release after immersion in Hank's solution was minor, far below the threatening threshold of daily diet. Murine fibroblast and osteoblast cell lines were indirectly co-cultured with experimental sample extracts, indicating no cytotoxicity. Amongst all samples, the nanocrystalline Ni50.2Ti49.8 shows promising as best biomaterial candidate for its good combination of mechanical property, corrosion resistance and cytocompatibility. |
| Keywords: | Ni50 2Ti49 8 alloy Nanocrystalline Amorphous Metals and alloys Corrosion and ion release Cytotoxicity |
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