羟丙基壳聚糖微球的制备与性能

以壳聚糖、环氧丙烷为原料合成羟丙基壳聚糖,以此为壳材,以胰岛素为芯材,制备微球,并考察微球的性能.单凝聚法制备微球.通过IR、XRD和DSC表征微球的化学结构,采用光学显微镜和扫描电镜观察微球的形貌,并考察微球稳定性.搅拌速度为400 r/min、交联荆用量为0.15 mL、HPCS浓度为8%,得到的微球形状规整,包埋率为63%,粒径大小适中,分布范围窄;各种环境下稳定性合适.羟丙基壳聚糖包覆胰岛素微球各种性能研究表明:此载药微球满足药用需要.

Preparation and Property of Hydroxypropyl Chitosan Microspheres

Hydroxypropyl chitosan was synthesized from chitosan and propylene oxide. Using it as the shell material,insulin as the core was prepared microspheres single-pool preparation and the performance of microspheres was studied. Microspheres was prepored by single coacervation. The microspheres chemical structure was characterized by IR,XRD and DCS,morphology was observation using optical microscopy and scanning electron microscopic and the stability of microspheres was inspected. When stirring speed was 400 r/min, crosslinker dosage 0.15 mL, hydroxypropyl-chitosan concentration was 8 % , the shape of microspheres were better,encapsulation efficiency was 63 % .particle size was medium and distribution narrow was scope. The stability was appropriate under a variety of environmental. Microspheres of hydroxypropyl chitosan coated insulin performance studies was showed that the microspheres met the medical need.