| 钆携带剂用于中子俘获治疗的现状及进展北大核心CSCD |
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| 引用本文： | 韩祎,崔大庆,李纪元,刘志博.钆携带剂用于中子俘获治疗的现状及进展北大核心CSCD[J].核化学与放射化学,2022,44(3):339-346. |
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| 作者姓名： | 韩祎 崔大庆 李纪元 刘志博 |
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| 作者单位： | 中国原子能科学研究院 放射化学研究所，北京102413;斯德哥尔摩大学 材料与环境化学系，瑞典SE-106 91;北京大学 化学与分子工程学院，北京100871;北京大学 清华大学生命联合中心，北京100871 |
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| 摘 要： | 钆中子俘获治疗(gadolinium neutron capture therapy,GdNCT)是一种基于热中子与钆(gadolinium,Gd)之间的俘获反应对肿瘤细胞产生损伤的新疗法。钆中子俘获治疗的优势在于,钆在所有自然元素中具有最高的热中子俘获截面;含钆造影剂广泛应用于核磁共振成像(magnetic resonance imaging,MRI)。为了提高GdNCT的治疗效果,已经有多种方法对钆携带剂进行改进。本文阐述了钆中子俘获治疗的原理,总结了提高钆携带剂在中子俘获治疗过程中治疗效果的多种策略,为将来GdNCT的临床应用提供新的思路。
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| 关 键 词： | 钆中子俘获治疗 中子俘获治疗 靶向治疗 |
State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy |
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| HAN Yi,CUI Da-qing,LI Ji-yuan,LIU Zhi-bo.State and Progress of Gadolinium-Based Agents for Neutron Capture Therapy[J].Journal of Nuclear and Radiochemistry,2022,44(3):339-346. |
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| Authors: | HAN Yi CUI Da-qing LI Ji-yuan LIU Zhi-bo |
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| Affiliation: | China Institute of Atomic Energy, P. O. Box 275(26), Beijing 102413, China;Department of Materials and Environmental Chemistry, Stockholms University, SE 106 91, Sweden;College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;Tsinghua University Peking University Joint Center for Life Sciences, Beijing 100871, China |
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| Abstract: | Gadolinium neutron capture therapy(GdNCT) is an innovative treatment that exert damage on tumor cells based on the capture reaction between thermal neutron and gadolinium. In comparison with other types of neutron capture therapy(NCT), gadolinium has the highest thermal capture cross section of any natural elements. Gadolinium based agents are widely used in magnetic resonance imaging(MRI) as contrast agents. The improvements of multiple gadolinium based agents have been applied to enhance therapeutic efficacy of GdNCT. In this review, principles of gadolinium neutron capture therapy were studied and diverse strategies to improve therapeutic efficacy of gadolinium based agents were summarized. Giving a perspective on GdNCT to prompt its clinical use. |
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| Keywords: | GdNCT NCT targeted therapy |
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