| HPLC Method for the Determination of Tamsulosin Hydrochloride in Sustained Release Tablets |
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| 引用本文： | 齐美玲,王鹏,耿颖姝,顾峻岭. HPLC Method for the Determination of Tamsulosin Hydrochloride in Sustained Release Tablets[J]. 北京理工大学学报(英文版), 2003, 12(2): 194-197 |
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| 作者姓名： | 齐美玲 王鹏 耿颖姝 顾峻岭 |
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| 作者单位： | [1]DepartmentofChemistry,SchoolofScience,BeijingInstituteofTechnology,Beijing100081,China [2]SchoolofPharmaceuticalEngineering,ShenyangPharmaceuticalUniversity,Shenyang,Liaoning110015,China [3]ShenyangPharmtechInstituteofPharmaceuticals,Shenyang,Liaoning110015,China |
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| 摘 要： | The development and validation of an isocratic high performance liquid chromatographic method is de-scribed for the determination of tamsulosin hydrochloride in sustained release tablets. The determination was per-formed on a Diamonsil BDS C18 column with a mobile phase consisting of a mixture of acetonitrile, methanol and 0.5% phosphoric acid solution (20:30:50, V/V/V) at a flow rate of 1.0 mL/min. UV detection was made at 274 nm. The linear range for tamsulosin hydrochloride was 0.81 - 8.10μg/mL. The mean recovery was 99.8%(SR = 0.7 %, n = 9), and the precision was found to be 0.45 % ( n = 9). The proposed method can be used for routine analysis of tamsulosin hydrochloride in sustained release tablets.
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| 关 键 词： | 高效液相色谱分析 HPLC 药物分析 前列腺增生 治疗 缓释剂 盐酸坦索罗辛 |
| 收稿时间： | 2002-04-17 |
HPLC Method for the Determination of Tamsulosin Hydrochloride in Sustained Release Tablets |
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| QI Mei ling,WANG Peng,GENG Ying shu and GU Jun ling. HPLC Method for the Determination of Tamsulosin Hydrochloride in Sustained Release Tablets[J]. Journal of Beijing Institute of Technology, 2003, 12(2): 194-197 |
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| Authors: | QI Mei ling WANG Peng GENG Ying shu GU Jun ling |
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| Affiliation: | Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, China;School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, Liaoning 110015, China;Shenyang Pharmtech Institute of Pharmaceuticals, Shenyang, Liaoning 110015, China |
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| Abstract: | The development and validation of an isocratic high performance liquid chromatographic method is described for the determination of tamsulosin hydrochloride in sustained release tablets. The determination was performed on a Diamonsil BDS C18 column with a mobile phase consisting of a mixture of acetonitrile, methanol and 0.5% phosphoric acid solution (20∶30∶50,V/V/V) at a flow rate of 1.0 mL/min. UV detection was made at 274 nm. The linear range for tamsulosin hydrochloride was 0.81-8.10 μg/mL. The mean recovery was 99.8% (SR=0.7%, n=9), and the precision was found to be 0.45% (n=9). The proposed method can be used for routine analysis of tamsulosin hydrochloride in sustained release tablets. |
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| Keywords: | HPLC tamsulosin hydrochloride sustained release tablets |
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