Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children |
| |
Authors: | ME Lai AP Mazzoleni F Argiolu S De Virgilis A Balestrieri RH Purcell A Cao P Farci |
| |
Affiliation: | Institute of Internal Medicine, University of Cagliari, Italy. |
| |
Abstract: | We investigated the course of distinct episodes of acute non-A, non-B (NANB) hepatitis in three polytransfused thalassaemic children. In each case, the first episode was associated with the appearance of serum hepatitis C virus (HCV) RNA and anti-HCV seroconversion. The second episode was accompanied by the reappearance of HCV viraemia, which in two patients was due to reinfection with a different HCV strain and in the third could be the result of either reactivation of primary infection or reinfection with a new but closely related strain. Thus HCV infection may not induce protective immunity, which has implications for vaccine development. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|