Creep-resistant dextran-based polyurethane foam as a candidate scaffold for bone tissue engineering: Synthesis,chemico-physical characterization,and in vitro and in vivo biocompatibility |
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| Authors: | I. Gerges M. Tamplenizza S. Lopa C. Recordati F. Martello A. Tocchio |
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| Affiliation: | 1. Fondazione Filarete per le Bioscienze e l’innovazione, Milan, Italy;2. Tensive s.r.l., Milan, Italy;3. Cell and Tissue Engineering Laboratory, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy;4. SEMM, European School of Molecular Medicine, Campus IFOM-IEO, Milano, Italy |
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| Abstract: | A highly crosslinked composite dextran-based scaffold (named DexFoam) was tailored to overcome specific deficiencies of polymeric and ceramic bone scaffolds and to guarantee a bone-mimicking microenvironment for the proliferation of human mesenchymal stem cells in vitro. The creep resistance for up to 90% compressive stain, the capability to regain the original shape after deformation, and the good thermal stability in both physiological and “body limit” conditions make DexFoam a valid alternative to the currently available bone scaffolds. Histopathological evaluation for host reaction and tissue colonization of DexFoam scaffold, implanted subcutaneously in mice, demonstrated its in vivo biocompatibility and biodegradability. |
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| Keywords: | Bone graft substitute composite scaffolds dextran polyurethane regenerative medicine tissue engineering |
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