Hemocompatible biomaterials of zwitterionic sulfobetaine hydrogels regulated with pH-responsive DMAEMA random sequences |
| |
| Authors: | Antoine Venault Chun-Wei Huang Jie Zheng Arunachalam Chinnathambi Sulaiman Ali Alharbi Yu Chang |
| |
| Affiliation: | 1. R&2. D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li City, Taiwan;3. Chemical &4. Biomolecular Engineering, The University of Akron, Akron, OH, USA;5. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia;6. Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;7. Department of Obstetrics and Gynecology, E-Da Hospital, I-Shou University, Kaohsiung City, Taiwan |
| |
| Abstract: | Polyzwitterionic biomaterial with pH-responsive and hemocompatible dual functions is formulated by the copolymerization of 2-(N, N-dimethyl amino) ethyl methacrylate (DMAEMA) sequences and sulfobetaine methacrylate (SBMA) moieties. Hydrogels are salt responsive, due to the interplay between hydrogen bonds formation, ions solvation, and antipolyelectrolyte effect, while DMAEMA sequences provide pH-responsiveness. Their low-fouling nature is demonstrated using plasma proteins and bacteria. Improved hemocompatibility with SBMA content is unveiled by the resistance to platelet and erythrocyte attachment, as well as from delayed plasma clotting time. Overall, this study suggests that dual-functional zwitterionic hydrogels are promising pH-responsive and hemocompatible polymeric biomaterials. |
| |
| Keywords: | Antifouling hemocompatible pH responsive poly(DMEAMA-co-SBMA) zwitterionic hydrogel |
|
|
