Poly(DL-lactide-co-ε-caprolactone) and poly(DL-lactide-co-glycolide) blends for biomedical application: Physical properties,cell compatibility,and in vitro degradation behavior |
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| Authors: | Tiziana Nardo Valeria Chiono Piergiorgio Gentile Maryam Tabrizian Gianluca Ciardelli |
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| Affiliation: | 1. Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, Italy;2. Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada;3. School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom;4. Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada |
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| Abstract: | Poly(DL-lactide-co-ε-caprolactone) (PLCL) and poly(DL-lactide-co-glycolide) (PLGA) blends of various compositions were prepared. Fractured sections of PLCL/PLGA blends did not evidence phase separation and blend glass transition temperatures suggested some degree of blend compatibility. The elastic modulus showed a negative deviation from the additive law of mixture. Superior biocompatibility in terms of fibroblast NIH 3T3 cell adhesion and proliferation, better mechanical properties, and a more homogeneous phase were obtained with PLCL/PLGA 25/75 blend. Rapid degradation of PLCL phase (4–8 weeks) in PLCL/PLGA 25/75 blend led to a porous structure, which makes it a potential candidate for drug delivery systems. |
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| Keywords: | Cast blend film compatibility between blend components poly(DL-lactide-co-ε-caprolactone) poly(DL-lactide-co-glycolide) regenerative medicine device |
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