Magnetic composite scaffolds of polycaprolactone/nFeHA,for bone-tissue engineering |
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| Authors: | E Díaz M B Valle J M Barandiarán |
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| Affiliation: | 1. ETS Náutica y Máquinas Navales, Departamento de Ingeniería Minera, Metalúrgica y Ciencia de Materiales, Universidad del País Vasco (UPV/EHU), Portugalete, Spain;2. Facultad de Ciencia y Tecnología (UPV/EHU), Leioa, Spain;3. BCMaterials, Parque Tecnológico de Bizkaia, Derio, Spain |
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| Abstract: | Magnetic composite scaffolds of polycaprolactone/Fe doped nanohydroxyapatite (PCL/nFeHA) with different composition ratios have been fabricated lyophilization for the purpose of bone-tissue engineering. Magnetic measurements reveal some interaction between the Fe particles that decreases steadily as the nFeHA is diluted in the polymer. All the scaffolds were characterized before and after in vitro degradation for over 28 weeks. The nFeHA nanoparticles decreased the initiation rate of hydrolytic degradation. After 16 weeks degradation, thermograms of the first heating revealed two melting peaks, which could be attributed to the presence of crystals of two different sizes. GPC results indicated that Mw and Mn were unaffected by the degradation with no cleavage of the macromolecular chains. |
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| Keywords: | Biodegradable polymers magnetic nanoparticles bone repair scaffolds in vitro degradation |
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