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Nanoengineered biocomposite tricomponent polymer based matrices for bone tissue engineering |
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| Authors: | Ewa Kijeńska Sai Zhang Seeram Ramakrishna Wojciech Swieszkowski |
| Affiliation: | 1. Center for Nanofibers and Nanotechnology, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore;2. Materials Design Division, Faculty of Material Science and Engineering, Warsaw University of Technology, Warsaw, Poland;3. Key Laboratory of Textile Science &4. Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, China;5. Materials Design Division, Faculty of Material Science and Engineering, Warsaw University of Technology, Warsaw, Poland |
| Abstract: | Nanoengineered biodegradable constructs based on synthetic and natural polymers enriched with hydroxyapatite (HA) nanoparticles have been found to mimic the extracellular matrix of bone tissue. The main objective of this study was to create biocomposite nanostructured scaffolds by incorporating collagen and HA nanoparticles into poly(L-lactic acid)-co-poly(?-caprolactone) by electrospinning. The fiber diameter of the composite PLCL/Col and PLCL/Col/HA fibers was smaller compared to PLCL. In vitro biocompatibility of the scaffolds studied using human fetal osteoblasts and EDX analysis showed high deposition of calcium on PLCL/Col/HA. The results shows that PLCL/Col/HA nanofibrous constructs have huge potential as substrates for bone regeneration. |
| Keywords: | Collagen mineralization nanofibers nanohydroxyapatite osteoblasts |