Potential application of gelatin scaffolds prepared through in situ gas foaming in skin tissue engineering |
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| Authors: | S Ali Poursamar Javad Hatami Alexander N Lehner Cláudia L da Silva Frederico Castelo Ferreira A P M Antunes |
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| Affiliation: | 1. Institute for Creative Leather Technologies, Park Campus, The University of Northampton, Northampton, England;2. Department of Bioengineering and IBB, Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal;3. Centre for Physical Activity and Chronic Disease and the Aging Research Centre, Institute for Health and Wellbeing, School of Health, Park Campus, The University of Northampton, Northampton, England |
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| Abstract: | Gelatin’s excellent foaming ability allows the application of in situ gas foaming as a preparation technique for porous scaffold development. Here, a new iterative experimental design for in situ gas foaming method is reported. The prepared scaffolds were studied for applying the findings to the future skin tissue engineering scaffolds. The thermal stability, mechanical properties, and pore structure of the scaffolds are reported and their degradation resistance by using collagenase enzyme and their cytotoxicity by using fibroblasts were studied. The results of this study demonstrated that gas foaming method can be modified to produce an interconnected porous structure with enhanced mechanical properties. |
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| Keywords: | Gelatin wound dressing gas foaming tensile strength cytotoxicity |
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