新生儿缺氧缺血性脑病IGF-1测定及其临床意义

目的 研究新生儿缺氧缺血性脑病（Hypoxic ischemic encephalopathy,HIE）血清胰岛素样生长因子-1（insulin-like growth factor-1,IGF-1）的水平及其临床意义.方法 采用放射免疫法（Radioimmunoassay,RIA）测定30例正常对照、60例HIE患儿急性期及恢复期IGF-1含量,其中HIE轻、中、重度各20例.结果 新生儿HIE急性期及恢复期的血清IGF-1的含量均显著低于正常对照组（P〈0.01）,但恢复期IGF-1含量相对于急性期有明显升高（P〈0.01）.急性期HIE轻、中、重度各组间的IGF-1含量差异均有统计学意义（P〈0.01）,病情越重,IGF-1含量越低.结论 HIE患儿血清IGF-1含量的降低与HIE的病理生理过程密切相关,可作为病情严重程度的监控指标.并为临床应用IGF-1治疗HIE提供理论依据.

Detection of Insulin-Like Growth Factor-1 and Its Clinical Significance in Neonatal Hypoxic Ischemic Encephalopathy

Objective To study the serum insulin-like and their clinical significance in newborns with hypoxic Serum IGF-1 levels were detected by radioimmunoassay, growth factor-1 （IGF-1） concentrations ischemic encephalopathy（HIE）. Methods in 30 normal controls and 60 newborns with HIE in acute and recovery period. Furthermore,these HIE newborns were divided into three group： mild,moderate and severe,with 20 newborns in each group. Results The levels of IGF-1 in newborns with HIE in acute and recovery period were significantly lower than those in normal eontrols（P〈0.01）, but IGF-1 levels in recovery period were significantly higher than those in a- cute period （P〈0.01）. There were obvious differences in IGF-1 levels among mild,moderate and severe groups（P〈0.01）. The severity of illness increased with the reduction of IGF-1 levels. Con- clusion The decreased IGF-1 levels are correlated with the pathophysiological process of HIE in newborns. Therefore,IGF-1 levels can be used as an index to monitor the severity of illness and may provide a theoretical basis for IGF-1 treatment of HIE.