Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial |
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Authors: | Erlin Zhang Haiyan Chen Feng Shen |
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Affiliation: | (1) Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China;(2) Graduate University of Chinese Academy of Sciences, Beijing, 100049, China;(3) School of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150001, China |
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Abstract: | Biocorrosion properties and blood- and cell compatibility of pure iron were studied in comparison with 316L stainless steel
and Mg–Mn–Zn magnesium alloy to reveal the possibility of pure iron as a biodegradable biomaterial. Both electrochemical and
weight loss tests showed that pure iron showed a relatively high corrosion rate at the first several days and then decreased
to a low level during the following immersion due to the formation of phosphates on the surface. However, the corrosion of
pure iron did not cause significant increase in pH value to the solution. In comparison with 316L and Mg–Mn–Zn alloy, the
pure iron exhibited biodegradable property in a moderate corrosion rate. Pure iron possessed similar dynamic blood clotting
time, prothrombin time and plasma recalcification time to 316L and Mg–Mn–Zn alloy, but a lower hemolysis ratio and a significant
lower number density of adhered platelets. MTT results revealed that the extract except the one with 25% 24 h extract actually
displayed toxicity to cells and the toxicity increased with the increasing of the iron ion concentration and the incubation
time. It was thought there should be an iron ion concentration threshold in the effect of iron ion on the cell toxicity. |
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