| 乳铁蛋白体外和体内铁结合能力的研究 |
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| 引用本文： | 卢蓉蓉,孙震,许时婴. 乳铁蛋白体外和体内铁结合能力的研究[J]. 食品科学, 2006, 27(5): 113-118 |
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| 作者姓名： | 卢蓉蓉 孙震 许时婴 |
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| 作者单位： | 江南大学食品学院； 食品科学与安全教育部重点实验室 |
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| 摘 要： | 采用超滤-离子交换色谱法制备的乳铁蛋白的铁结合能力为87.7%,铁饱和度为15.1%。当pH值为7.5,NaHCO3浓度为100mmol/L时,铁结合能力最强。采用低强度的巴氏杀菌可以保持乳铁蛋白的铁结合性能。SD大鼠的动物试验表明,50μg/g·d和250μg/g·d的乳铁蛋白剂量具有显著的升高血红蛋白浓度的作用。乳铁蛋白改善缺铁性贫血的最小有效作用剂量为50μg/g·d。
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| 关 键 词： | 乳铁蛋白 铁结合能力 |
| 文章编号： | 1002-6630（2006）05-0113-06 |
| 收稿时间： | 2005-02-28 |
| 修稿时间： | 2005-02-28 |
Iron-Binding Capacity of Lactoferrin in vitro and in vivo |
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| LU Rong-rong,SUN Zhen,XU Shi-ying. Iron-Binding Capacity of Lactoferrin in vitro and in vivo[J]. Food Science, 2006, 27(5): 113-118 |
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| Authors: | LU Rong-rong SUN Zhen XU Shi-ying |
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| Affiliation: | 1.School of Food Science and Technology, Southern Yangtze University, Wuxi 214036, China; 2.Key Laboratory of Food Science and Safety; Ministry of Education, Wuxi 214036, China |
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| Abstract: | The iron-binding capacity of lactoferrin was 87.7% produced by ultrafiltration and strong cation exchange chromatography. Its iron saturation point was 15.1%. Lactoferrin exhibited the strongest iron binding capacity at pH7.5 and 100 mmol/L of bicarbonate. In vivo study with SD rats showed that LF could significantly increase the concentration of hemoglobin at doses 50μg/g·d and 250μg/g·d. The low marginal dose level of LF was 50μg/g·d. |
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| Keywords: | lactoferrin iron-binding capacity |
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