| 5-羟基色满的合成 |
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| 引用本文： | 黄二芳,朱丽丹,孙蕊,金丽萍,胡春. 5-羟基色满的合成[J]. 精细化工中间体, 2006, 36(6): 20-21 |
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| 作者姓名： | 黄二芳 朱丽丹 孙蕊 金丽萍 胡春 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016;沈阳药科大学,制药工程学院,辽宁,沈阳,110016;沈阳药科大学,制药工程学院,辽宁,沈阳,110016;沈阳药科大学,制药工程学院,辽宁,沈阳,110016;沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 基金项目： | 国家自然科学基金资助项目(20472053) |
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| 摘 要： | 以2',6'-二羟基苯乙酮为起始原料,在钠催化下和甲酸乙酯缩合制得5-羟基-4-色酮,然后催化氢化还原得到5-羟基-4-色满酮,最后用锌汞齐还原制得5-羟基色满。所设计的5-羟基色满合成路线总收率能达到37%,是合成5-羟基色满的新路线。
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| 关 键 词： | 药物化学 5-羟基色满 5-羟基-4-色酮 5-羟基-4-色满酮 合成 Clemmensen还原 催化氢化 |
| 文章编号： | 1009-9212(2006)06-0020-02 |
| 收稿时间： | 2006-10-29 |
| 修稿时间： | 2006-10-29 |
Study on Synthesis of 5-Hydroxychroman |
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| HUANG Er-fang,ZHU Li-dan,SUN Rui,JIN Li-ping,HU Chun. Study on Synthesis of 5-Hydroxychroman[J]. Fine Chemical Intermediates, 2006, 36(6): 20-21 |
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| Authors: | HUANG Er-fang ZHU Li-dan SUN Rui JIN Li-ping HU Chun |
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| Affiliation: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | 5-Hydroxychroman was prepared by Clemmensen reduction from 5-hydroxy-4-chromanone,whereas 5-hydroxy-4-chromanone was prepared by catalytic hydrogenation from 5-hydroxy-4-chromone which was prepared from2',6'-dihydroxyacetophenone.5-Hydroxychroman can be synthesized with total yield of 37% according to the novel procedure reported in this paper. |
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| Keywords: | medicinal chemistry 5-hydroxychroman 5-hydroxy-4-chromone 5-hydroxy-4-chromanone synthesis clemmensen reduction catalytic hydrogenation |
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