氧乐果对小鼠心脏的氧化损伤以及抗氧化维生素的防护作用

本文研究了有机磷杀虫剂氧乐果对小鼠心脏的氧化损伤以及抗氧化维生素E、C的防护作用。结果表明,随着氧乐果染毒剂量的增加,小鼠心脏超氧化物歧化酶(SOD)活力降低,高剂量氧乐果染毒使SOD活力明显降低,与对照组比较差异显著(p<0.05);小鼠心脏脂质过氧化产物丙二醛(MDA)含量随着氧乐果染毒剂量的增加而升高,高剂量氧乐果染毒使MDA含量明显升高,与对照组比较差异显著(p<0.05)。抗氧化维生素E、C对氧乐果引起的小鼠心脏氧化损伤均有一定的拮抗作用。

Oxidative Damage Induced by Omethoate in Mice Heart and Its Protection Role of Antioxidative Vitamin

Objective: To study oxidative damage of mice heart induced by omethoate. Methods: The mice were divided into 8 groups(control 1 group, vitamin E 2 group, vitamin C 3 group, 2.5mg/kg omethoate 4 group, 5mg/kg omethoate 5 group, 10mg/kg omethoate6 group, 10mg/kg omethoate 800mg/kg vitamin E 7 group and 10mg/kg omethoate 400mg/kg vitamin C 8 group,with 12mice/group)and perfusion fed for 7d. Results: The activities of SOD in heart were decreased with dosage increasing of omethoate, and in 10mg/kg omethoate group ,the activities of SOD were significantly decreased than those in control group. MDA increased sighificantlyat 10mg/kg omethoate and showed obvious positive correlationship between omethoate doses and MDA. Vitamin E and vitamin Ccould inhibite the decrease of SOD activities and increase of MDA. Conclusion: Omethoate could induce lipid peroxidation in heartof mice. Vitamin E and vitamin C could prevent oxidative damage of heart induced by omethoate to a certain degree.