| 纳米级磁性壳聚糖微球的靶向性研究 |
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| 引用本文： | 孙井辉,王红英,钱斯日古楞,庞文静.纳米级磁性壳聚糖微球的靶向性研究[J].材料导报,2011(Z1). |
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| 作者姓名： | 孙井辉 王红英 钱斯日古楞 庞文静 |
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| 作者单位： | 大连工业大学生物工程学院; |
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| 基金项目： | 辽宁省教育厅A类项目(2008063) |
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| 摘 要： | 纳米级磁性微球作为磁性药物靶向治疗中的一种重要载体,通过外加磁场作用可在靶向部位大量聚集,提高靶区药物浓度。通过研究磁性微球(MCM)的制作和动物的靶向实验,探索了纳米级磁性壳聚糖微球的靶向性。实验中将大鼠分为3组:1#为靶向组,2#为非靶向组,3#为空白对照组。通过原子吸收和红外光谱等方法检测了各组大鼠体内靶向组织肝脏中的铁离子含量,1#的肝脏中铁离子含量明显高于其它组,表明纳米级磁性壳聚糖微球具有良好的靶向性。
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| 关 键 词： | 磁性微球 靶向性 原子吸收 红外光谱 |
Research on Targeting of Nanoparticle Magnetic Chitosan Microspheres |
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| SUN Jinghui,WANG Hongying,QIAN Siriguleng,PANG Wenjing.Research on Targeting of Nanoparticle Magnetic Chitosan Microspheres[J].Materials Review,2011(Z1). |
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| Authors: | SUN Jinghui WANG Hongying QIAN Siriguleng PANG Wenjing |
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| Affiliation: | SUN Jinghui,WANG Hongying,QIAN Siriguleng,PANG Wenjing (School of Biological Engineering,Dalian Polytechnic University,Dalian 116034) |
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| Abstract: | As an important carrier for target therapy by magnetic medicine,magnetic microspheres could be concentrated at the target site by the applied magnetic field,consequently,the concentration of target medicine could be increased.The targeting of nanoparticle magnetic chitosan microspheres was found through researching the process of magnetic microsphere and target experiment at animals.The lab rats were divided into three groups:targeting group is the first one,none-targeting group is the second one and the la... |
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| Keywords: | magnetic microspheres targeting atomic absorption spectrometry infrared spectroscopy |
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